Smithia sensitiva belonging to the family Fabaceae is a plant used as an anti inflammatory and anti-oxidant drug by tribal peoples in kerala. The isolation and characterization of phytoconstituents will help to evaluate which type of active constituent may be responsible for potent pharmacological activity. Therefore in the present study, initiatives were taken to explore different extracts of the plant for isolating active constituents and to characterize the isolated compounds so that it will be helpful to determine which type of active constituent may be responsible for making it a potent anti-inflammatory plant. The inhibitory effect of compounds isolated from MESS on in-vitro enzymatic activities were measured against COX 1 and COX 2. In this study the compound III at a concentration of 50 µg/ml displayed more COX 2 inhibition. Compounds III from methanoloic extract of Smithia sensitiva (MESS) showed maximum % inhibition (80.59). It can be concluded that the activity related to MESS mainly due to the presence of flavonoids and triterpenoids.
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